DEPRESSIVE SYMPTOMATOLOGY, HIPPOCAMPAL VOLUME, AND CONTEXTUAL MEMORY IN LATE LIFE GENERALIZED ANXIETY DISORDER: AN MRI STUDY by
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Abnormalities in hippocampal functioning with persistent pain.
Chronic pain patients exhibit increased anxiety, depression, and deficits in learning and memory. Yet how persistent pain affects the key brain area regulating these behaviors, the hippocampus, has remained minimally explored. In this study we investigated the impact of spared nerve injury (SNI) neuropathic pain in mice on hippocampal-dependent behavior and underlying cellular and molecular cha...
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It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset of depressive disorders. Given the critical role of the hippocampus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental co...
متن کاملConfigural cue performance in identical twins discordant for posttraumatic stress disorder: theoretical implications for the role of hippocampal function.
BACKGROUND A significant subgroup of individuals with posttraumatic stress disorder (PTSD) exhibits chronic, unremitting symptomatology that has also been associated with smaller hippocampal volume. The hippocampus plays a significant role in configural processing of contextual cues that facilitates context-appropriate extinction of conditioned fear. We test the hypothesis that hippocampus-base...
متن کاملEffects of early-life stress on cognitive function and hippocampal structure in female rodents.
We tested the effect of early-life stress (ELS) - 24h maternal deprivation (MD) at postnatal day (PND) 3 - on cognitive performance and hippocampal structure in 12-17-week-old female rats. Behavioral performance was examined in: the Elevated Plus Maze, as an index for general anxiety; the rodent Iowa gambling test, probing reward-based decision making; and the object recognition and object-in-l...
متن کاملHippocampal Contribution to Context Encoding across Development Is Disrupted following Early-Life Adversity.
Context can drastically influence responses to environmental stimuli. For example, a gunshot should provoke a different response at a public park than a shooting range. Little is known about how contextual processing and neural correlates change across human development or about individual differences related to early environmental experiences. Children (N = 60; 8-19 years, 24 exposed to interp...
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تاریخ انتشار 2010